منابع مشابه
The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause insulin resistance. Ceramides can readily cross the blood-brain barrier, and ceramide exposure cause...
متن کاملParacetamol, alcohol and the liver.
It is claimed that chronic alcoholics are at increased risk of paracetamol (acetaminophen) hepatotoxicity not only following overdosage but also with its therapeutic use. Increased susceptibility is supposed to be due to induction of liver microsomal enzymes by ethanol with increased formation of the toxic metabolite of paracetamol. However, the clinical evidence in support of these claims is a...
متن کاملAlcohol and liver damage
Chronic heavy drinking can cause the liver to become fatty. Fat deposits in the liver block the liver cells from their blood supply, depriving them of oxygen and other nutrients, eventually killing them. As the name implies, the liver performs so many vital functions that we cannot live without it. The liver filters all of the blood in our bodies, breaking down and eliminating toxins, convertin...
متن کاملAlcohol and liver damage.
The association of aicohol with cirrhosis was recognised by~vfatthew Ba-ilhe4& 1793 and later by Addison. In Western countries the incidence of cirrhosis canbe directly related to the quantity of aicohol consumed. In France, between—1941 and 1947, rationing of wine from five to one litre per week led to an 80% reduction in mortaiity from cirrhosis (1). Cirrhosis is on the increase. In the U.S.A...
متن کاملSevere alcohol-induced liver disease and the alcohol dependence syndrome.
AIMS To examine the hypothesis that patients who present in the UK to detoxification services differ from patients who present with severe alcohol-induced liver disease (ALD) with respect to severity of dependence on alcohol and other features of their drinking history. METHODS Levels of alcohol dependence were assessed in 34 patients with severe ALD, all of whom were cirrhotic, and 34 subjec...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1987
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107688708000722